July 20, Precision medicine: a deep breakthrough in life sciences paradigm.
Bioscience - Lost In Translation? - How Precision Medicine Closes The Innovation Gap Paperback
Bioscience - Lost in Translation? How precision medicine closes the innovation gap It is not so easy to translate knowledge into practice, and this is the case of biosciences into clinical applications. However, recently this trend is accelerating and precision medicine is emerging.
A new book gives us the highlights to understand precisely what's going on: Bioscience - Lost in Translation?
How precision medicine closes the innovation gap. This was the best that medicine could do when external observation of the patient was the only or primary means of diagnosing disease. Molecular level diagnosis becomes a real possibility. Such an approach brings effective therapy immediately closer. Molecular diagnostics can separate diseases with similar symptoms but different underlying causes— and often suggest a different starting point for intervention.
If this is so, what should we do? The seven changes of mindset and of practice are: 1. Advance the molecular definition of disease and the application of systems biology.
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And we need to marry this with a recognition that singular target- based innovation rarely works: we need a systems biology approach. Partner academia and industry in more collaborative, impact- oriented research. We need to define new pre- or non- competitive spaces, especially in work on disease mechanisms and disease models. And we need to provide for new types of links and incentives to break down the barriers between these two worlds. Move decisively to a more adaptive approach to development, trial and approval design.
Advisory Board Member Richard Barker Presents at Basel Life Science Week
We need to build on successful experiments in more flexible trial design, development pathways, and regulatory appraisal to a globally accepted adaptive approach. This involves collaborative design of the evidence package needed to secure approval and reimbursement, and greater teamwork through the process.
Create new reward and financing vehicles for leading edge innovation. We need to move from reward systems based purely on unit sales of products, irrespective of outcome, to rewarding innovators for positive outcomes, patient by patient. We also need to design financing mechanisms that bridge between cost- effectiveness and affordability.
We must be able to accommodate high- cost precision therapies that offer cures and so generate long- term returns for the system. Engineer tools and systems for faster and better innovation adoption and adherence.
We need to move from reliance solely on promotion to doctors and passive patient participation to a disciplined approach to establishing new pathways of care. These will be based on modern behavioural science, clinical decision support, and other digital technologies. Develop an infrastructure for real- world data- driven learning.
We now have the opportunity to study in large populations how lifestyle and treatment choices lead to outcomes, learning from every patient as if in a clinical trial. New analytical tools will empower this. It is time to move from a process and mindset in which patients are regarded as passive subjects for clinical trials and recipients of products and procedures. Their input and engagement needs to be sought along the whole innovation chain: on treatment benefits, acceptable risks, optimal clinical trial design, adherence support, and outcomes. Highly recommended.
July 19, In search of the balance between government and market. The focus was clear, the government should enter when there is a market failure and try to curb it.
This was the message and has been the message for many years. Now we know that the approach was too simplistic. A well written and accessible book that helps to remake the arguments with the evidence of the past years. Market or Government? Rise and Fall of Capitalism: Linear or Cyclical?
The Euro is a Threat to the Market System The World of Piketty Pendulum Swings between Markets and Governments At the end of the book there are two issues that concern the author: inequality and the degradation of environment. Average rating: 0 out of 5 stars, based on 0 reviews Write a review. Director Richard Barker. Tell us if something is incorrect. Out of stock. Get In-Stock Alert. Delivery not available.
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